A Apple atualizou hoje os apps Pages, Numbers e Keynote com novidades voltadas principalmente aos assinantes do Apple Creator Studio.

Entre os destaques estão um assistente inteligente baseado em linguagem natural, novos conteúdos premium e, no caso do Keynote, suporte à importação e exportação de apresentações em um novo formato de arquivo aberto.

Além disso, os três agora podem aproveitar o maior espaço da tela aberta do iPhone Duo.

Assistente inteligente

Nos três aplicativos, o assistente inteligente — ainda em fase beta e apenas em inglês — permite executar tarefas por meio de comandos em linguagem natural, levando em consideração o conteúdo do documento, da planilha ou da apresentação em que o usuário está trabalhando.

No Pages, a ferramenta pode ajudar a iniciar e revisar textos, reorganizar conteúdos, ajustar o tom da escrita e gerar imagens e formas. Também é possível solicitar informações atualizadas sobre determinado assunto e incorporá-las ao documento.

Já o Numbers utiliza o recurso para ajudar a interpretar dados, criar tabelas, sugerir gráficos e elaborar fórmulas, além de pesquisar informações que possam ser incorporadas às planilhas.

No Keynote, o assistente pode gerar slides, criar notas para apresentações, produzir imagens e formas e ajudar a aprimorar o conteúdo e as animações. Assim como nos outros apps, também é possível pesquisar informações atualizadas para enriquecer o material.

Conteúdos premium

Os três aplicativos ganharam ainda novas coleções de conteúdos premium, incluindo modelos profissionais para documentos e planilhas e temas para apresentações. Os usuários também podem explorar o Content Hub, que reúne vídeos selecionados para adicionar elementos visuais e movimento aos seus projetos.

Novo formato de arquivo aberto

Uma novidade exclusiva do Keynote é o suporte, também ainda em versão beta, à importação e exportação de arquivos no formato KEYX. Trata-se de um formato aberto de intercâmbio que busca facilitar o uso de apresentações e de seus conteúdos fora do aplicativo da Apple.

Suporte ao iPhone Duo

Para completar, embora não tenha mencionado isso nas notas de versão, a Apple implementou suporte ao iPhone Duo nos três aplicativos, como notou o MacRumors.

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Vale reforçar que o assistente inteligente — além de estar disponível apenas em inglês e exigir um dispositivo compatível com a Apple Intelligence — e os novos conteúdos premium são exclusivos para assinantes do Apple Creator Studio.

Para quem não é assinante, os updates incluem apenas melhorias gerais, correções de bugs e aprimoramentos de desempenho.

Depois de suspender o desenvolvimento do Arc no início do ano passado, a The Browser Company anunciou hoje que está encerrando de vez o funcionamento do seu outrora popular navegador, forçando usuários a migrar para alternativas como o Dia — outro browser da casa.

A empresa explicou no site oficial do Arc que o fim do suporte ao navegador acontecerá em fases, culminando na sua morte definitiva em 22 de dezembro (tanto no macOS quanto no Windows).

We've decided to sunset Arc on December 22, 2026.

That's not an easy sentence to write. We spent years building Arc and celebrating each and every release along the way: we have so much pride and love for what we made alongside the Arc community.

Our priority is to deliver…

— Arc (@arcinternet) October 22, 2026

A partir de hoje, não é mais possível criar novas contas no Arc; em 23 de novembro, o recurso Browse for Me e outras ferramentas de inteligência artificial do navegador serão desativados, bem como a habilidade de “logar e sincronizar as suas abas”. Em 22/12, a The Browser Company também removerá o Arc Search do Google Play e desativará todas as contas de usuários.

Como comentamos no ano passado, a desenvolvedora abandonou o Arc para se dedicar ao Dia, que conta com um grande foco em IA. Na época, o diretor executivo da The Browser Company, Josh Miller, disse que sua equipe até considerou transformar o Arc em um navegador de código aberto, mas desistiu da ideia pois o kit de desenvolvimento de software (SDK, na sigla em inglês) do Arc ainda era valioso para a companhia.

Desde então, o Arc chegou a receber atualizações de segurança — algo que também será encerrado agora. Antes independente, a The Browser Company hoje é uma subsidiária da Atlassian (dona do Trello).

A Insta360 lançou hoje o Insta360 Mic, adição intermediária à sua linha de microfones (que já inclui o Mic Air e o Mic Pro), contando com uma tela eink personalizável e armazenamento expansível via microSD.

Pensado para criadores de conteúdo que buscam recursos mais sofisticados de áudio sem investir em um modelo topo de linha, ele é ideal para vlogs do cotidiano, gravações de esportes nos fins de semana, viagens, transmissões ao vivo e conversas em grupo.

O painel eink customizável permite a inserção de logos, emojis, animais de estimação, paisagens ou elementos da identidade visual do criador.

Para quem adquirir apenas o receptor, é possível utilizar o Insta360 Mic com as câmeras da fabricante (Insta360 X6, X5, Luna Ultra, Luna Pro, GO Ultra e Ace Pro 2), bem como com smartphones, tudo via Bluetooth. Outra alternativa para as gravações é o cartão microSD, que permite armazenar os áudios capturados pelo produto.

Com o cartão microSD inserido, o Mic é capaz de gravar áudios em ponto flutuante de 32 bits diretamente no transmissor e conta com um chip dedicado à supressão de ruído, baseada na NPU ¹Neural processing unit, ou unidade de processamento neural. do microfone, que reduz sons ambiente com maior intensidade.

O dispositivo tem dois modos de ganho automático: o Dynamic equilibra as variações de volume para manter a coesão sonora, enquanto o Auto ajuda a evitar a saturação de som. Ele conta ainda com três predefinições de timbre (Regular, Rich e Bright) para ajudar a preservar as características naturais da sonoridade captada.

Assim como o do Mic Pro, um único receptor do Mic se conecta a até quatro transmissores ao mesmo tempo, o que inclui produções com múltiplas câmeras (que podem receber o áudio de até dois receptores simultaneamente).

De acordo com a fabricante, cada transmissor possui até 13 horas de bateria com uma única carga, enquanto a case de carregamento amplia essa autonomia para até 34 horas.

Preço e disponibilidade

O Insta360 Mic está disponível na loja oficial da Insta360, com a seguinte relação de valores (em dólares) para o Brasil:

• Insta360 Mic (dois transmissores + um receptor): US$250;
• Insta360 Mic (um transmissor + um receptor): US$140;
• Um transmissor Insta360 Mic: US$80.

NOTA DE TRANSPARÊNCIA: O MacMagazine recebe uma pequena comissão sobre vendas concluídas por meio de links deste post, mas você, como consumidor, não paga nada a mais pelos produtos/serviços ao usar os nossos links de afiliado.

Notas de rodapé

• 1
  Neural processing unit, ou unidade de processamento neural.

Anunciado no final de 2024, o documentário do Apple TV sobre a lendária banda anglo-americana Fleetwood Mac ganhou hoje uma data de estreia: 29 de janeiro de 2027 — coincidindo com o aniversário de 50 anos do álbum “Rumours”, vencedor do Grammy.

Intitulada “Fleetwood Mac: The Chain”, a produção será dirigida pelo cineasta Frank Marshall, cinco vezes indicado ao Oscar, e contará com “as vozes, memórias e perspectivas” de todos os membros da banda (Mick Fleetwood, John McVie, Christine McVie, Lindsey Buckingham e Stevie Nicks), segundo a Maçã.

Com roteiro de Mark Monroe, o documentário busca refletir o profundo significado do hit “The Chain”, que “personifica uma família forjada por uma paixão compartilhada”, além de ser a única música do álbum “Rumours” creditada a todos os cinco membros.

A canção captura perfeitamente o vínculo complexo, porém duradouro, no coração do Fleetwood Mac, e sua letra icônica tornou-se um poderoso símbolo do respeito e da conexão que persistiram durante a tumultuada jornada da banda rumo ao estrelato.

Espectadores podem esperar reflexões sobre o álbum, os recordes batidos pela banda e suas turnês, bem como imagens nunca antes vistas e entrevistas inéditas realizadas ao longo das últimas décadas. O documentário promete ainda explorar a “resiliência pessoal e destreza musical” dos membros e levar os assinantes do Apple TV pelos altos e baixos da banda.

Além de dirigir, Marshall também produz pela The Kennedy/Marshall Company ao lado de Nigel Sinclair, Nicholas Ferrall, Jeanne Elfant Festa e Aly Parker. Cassidy Hartmann e Tony Rosenthal atuam como produtores executivos junto com Monroe.

O Apple TV está disponível no aplicativo Apple TV em mais de 100 países e regiões, seja em iPhones, iPads, Apple TVs, Macs, dispositivos Android, smart TVs ou online — além de estar em aparelhos como Roku, Amazon Fire TV, Chromecast com Google TV, consoles PlayStation e Xbox. O serviço custa R$34,90 por mês, com um período de teste gratuito de 7 dias. Por tempo limitado, quem comprar e ativar um novo iPhone, iPad, Apple TV ou Mac ganha 3 meses do Apple TV. Ele também faz parte do pacote de assinaturas da empresa, o Apple One.

NOTA DE TRANSPARÊNCIA: O MacMagazine recebe uma pequena comissão sobre vendas concluídas por meio de links deste post, mas você, como consumidor, não paga nada a mais pelos produtos/serviços ao usar os nossos links de afiliado.

Pull up any random photo of billionaire Anthropic CEO Dario Amodei, and you’re likely to land on a facial expression expressing something between horror and deep consternation. There may be a simple explanation for that: he knows the truth about his company’s finances.

New reporting by the Wall Street Journal revealed the mounting costs for the AI lab, which ballooned to a net loss of $80 billion in the first six months of 2026. Anthropic’s losses for the same period a year prior were $13 billion — still an eye-watering sum, but peanuts compared to its runaway spending this year (the WSJ called it “one of the largest half-year losses ever reported.”)

The bleak financial numbers come from a draft IPO prospectus viewed by the WSJ, which notes that the company’s revenue for the first half of 2026 grew by just $1.1 billion over the same period to $16.3 billion.

The figures add to the anxiety around how long the AI spending bubble can sustain itself. If Anthropic’s losses continue to mount at a rate far exceeding revenue growth, there’s simply no way the lab can dig itself out of the hole it’s burrowed for itself.

That would be bad news for the US economy as a whole, which now hinges almost entirely on circular AI investments and data center development.

Beyond the immediate losses, the WSJ notes that the AI lab is also footing a $450 billion bill for cloud computing infrastructure over the next seven to ten years — meaning the clock is ticking on what is surely the costliest game of “kick-the-can” the world has ever seen.

More on Anthropic: Anthropic Secretly Lobbying Government to Only Shut Down an AI Model If It’s Poised to Kill More Than 50 People

The post Anthropic’s Financial Situation May Explain Why Dario Amodei Looks So Terrified All the Time appeared first on Futurism.

Se você é daqueles usuários que não costumam deixar seus aplicativos do Mac abertos continuamente e têm uma rotina de abertura e fechamento bem definida, então o Cybokron Dock Groups pode ser uma mão na roda no seu workflow.

De código aberto, o app mora na barra de menus do sistema e permite, como seu próprio nome bem indica, agrupar programas para abri-los, ocultá-los e encerrá-los todos de uma vez — algo bem simples, rápido e prático.

Caso você tenha aplicativos que costuma abrir sempre que começa o trabalho e fechar no final do expediente, basta um clique no grupo correspondente para realizar uma ação. Inclusive, cada grupo pode ter seu próprio ícone no Dock.

Se você curtiu a proposta, o Cybokron Dock Groups pode ser baixado gratuitamente por essa página. Você também pode conferir o código-fonte no repositório oficial do app, no GitHub.

Fotografar em RAW é muito bom para fotógrafos ou entusiastas que querem obter um controle mais preciso de suas suas imagens na edição, mas o tamanho enorme dos arquivos gerados praticamente inviabiliza a sua distribuição nesse formato após a edição.

Por isso, geralmente os arquivos são convertidos para formatos mais eficientes antes de serem compartilhados, e o RawToHEIC é um software projetado especialmente com essa finalidade: transformar arquivos RAW no formato HEIC, amplamente usado pela Apple.

Ele é bem útil principalmente para profissionais que fazem o processo de edição de suas fotos diretamente no iPhone — por imagens em ProRAW capturadas do aparelho ou importadas de câmeras como Canon, Nikon, Sony, Fuji, Olympus, Panasonic, Pentax e Hasselblad.

Funcionando direto pelo menu de compartilhar do app Fotos (Photos), o app permite que você edite a foto direto no iPhone e a converta para o novo formato após a conclusão, mantendo coisas como HDR ¹High dynamic range, ou ampla faixa dinâmica. e metadados e ocupando até quase dez vezes menos armazenamento.

O RawToHEIC também funciona no iPadOS e no macOS — o que é ideal para quem gosta de fazer suas edições no aplicativo nativo da Maçã ou simplesmente não tem um aplicativo de edição capaz de exportar fotos em RAW para outros formatos com facilidade.

O app pode ser baixado gratuitamente e oferece até 50 conversões por dia. Para conversões ilimitadas, você pode assiná-lo por R$60/ano ou comprá-lo por R$130.

Notas de rodapé

• 1
  High dynamic range, ou ampla faixa dinâmica.

A nurse-led chronic disease management clinic in the urology department of a tertiary hospital recorded 14,013 outpatient registrations between July 2024 and September 2026, according to a single-center retrospective descriptive study using routinely collected service records. The clinic primarily supported long-term management of patients with prostate and bladder cancer while also providing specialty nursing services for other urological conditions. Its follow-up system marked 3,547 of 3,553 assigned tasks as successful, a task-level success rate of 99.83%. These figures describe service activity and record completion; the study did not measure whether the clinic improved clinical outcomes or economic performance.

The clinic was established in July 2024 within the hospital’s existing specialty nursing outpatient service framework. Its operating model included staffing and qualification requirements, professional training, clearly defined nursing responsibilities, physician–nurse collaboration, standardized procedures, information-system support and quality management. Nurses worked within their authorized scope of practice, while urologists participated in medical assessment and treatment decisions when required. The service had four reported components: patient assessment and follow-up planning; treatment follow-up and adverse-event monitoring; rehabilitation guidance and health promotion; and assistance with healthcare policies and basic nursing care.

Monthly registrations increased from 147 in July 2024 to a peak of 710 in August 2026, with fluctuations during the reporting period. Total registration fees were CNY 152,758. The clinic delivered 14,246 prostate cancer-related injections, 3,523 urinary catheterizations, 2,777 intravesical instillation procedures and 2,142 urinary catheter removals. It also assisted patients with prostate or bladder cancer in applying for outpatient chronic and special disease insurance benefits. The study reports these counts as routine service activities, but it did not compare the procedures with those delivered elsewhere or evaluate their individual clinical effects.

Follow-up management was integrated into the clinic’s information system, which contained records for 1,111 patients. Of these, 953 patients had been followed up and 951 had successful follow-up records. Nurses also executed 3,553 follow-up tasks, of which 3,547 were successful, corresponding to the reported 99.83% task-level rate. The descriptive data do not specify the duration or effectiveness of patient follow-up, assess whether missed contacts influenced treatment adherence or health outcomes, or establish how the results would compare with another care model.

Because the research covered one tertiary hospital and relied on routinely collected records, it cannot establish how the clinic would operate in smaller facilities, under different staffing arrangements or in other health systems. The findings offer a documented example of a nurse-led outpatient service with defined responsibilities, standardized workflows, follow-up documentation and collaboration with urologists. The authors stated that further research is needed to evaluate the model’s clinical outcomes and economic implications. Accordingly, the registration growth, procedural workload and high proportion of completed follow-up tasks should be interpreted as descriptions of implementation and recorded service delivery, not as evidence of improved survival, fewer complications, lower costs or other patient benefits.

Subject of Research: Operation and service activity of a nurse-led chronic disease management clinic in hospital urology

Article Title: Development and implementation of a nurse-led chronic disease management clinic in the urology department of a tertiary hospital: a descriptive study

Article References: Liu, C., Xia, Y., Jia, X., Wang, R., Li, T., Ma, Y., & Long, H. (2026). Development and implementation of a nurse-led chronic disease management clinic in the urology department of a tertiary hospital: a descriptive study. BMC Nursing. https://doi.org/10.1186/s12912-026-05566-z

Image Credits: AI Generated

DOI: 10.1186/s12912-026-05566-z

Keywords: nurse-led care, urology, outpatient nursing, chronic disease management, prostate cancer, bladder cancer, patient follow-up, service implementation, descriptive study, Development, implementation, nurse-led

The penalty, one of the largest levied against the tech giant, stemmed from a lawsuit by New Mexico claiming the social media company had misled users about their data privacy.

Sediments from a small mountain lake in Bosnia and Herzegovina preserve an approximately 16,000-year record of summer temperature change in the Western Balkans, revealing abrupt climatic shifts whose effects varied across Europe. Researchers at Eötvös Loránd University reconstructed past mean July temperatures from chironomid remains and other lake-sediment indicators, then used pollen, sediment particles, organic matter and geochemical elements to track associated changes in vegetation, erosion and lake conditions. Two peer-reviewed studies published in 2026 examine different periods in the same sequence, together covering the Late Glacial, the Holocene and more recent centuries.

The reconstructed record shows that a large cooling event associated with the Younger Dryas lowered estimated mean July temperatures at Lake Prokoško by approximately 2.3°C, a change intermediate between estimates from Alpine lakes and those farther east. The lake, which covers 4.8 hectares at an elevation of 1,670 metres in the Vranica Mountains of the Dinaric Alps, also records a later Middle Holocene interval in which estimated summer temperatures may have exceeded present-day levels. These findings emerge from a paleoclimate reconstruction based on biological, chemical and physical evidence preserved in lake sediments, rather than from direct instrumental measurements.

Lake Prokoško occupies a climatically significant position between Western, Central and Eastern Europe. Over thousands of years, remains from the surrounding landscape and the lake’s own ecosystem accumulated in bottom sediments, providing material for reconstructing regional environmental and climatic history. One study, published in Palaeogeography, Palaeoclimatology, Palaeoecology, focused on rapid changes between approximately 16,000 and 10,000 years ago during the Late Glacial and beginning of the Holocene. A separate study in Quaternary Science Reviews traced conditions through the Holocene to the present, extending the interpretation of the sediment sequence across the full period represented by the two investigations.

Chironomids, a group of aquatic insects also known as non-biting midges, supplied the principal temperature indicator. Their larvae occupy lake sediments and differ in their preferences for water temperature, oxygen levels and nutrient conditions. After moulting, larvae leave chitinous head capsules that sink to the lake bed, where they can be preserved for tens of thousands of years. The researchers identified the species represented in different sediment layers and compared the fossil assemblages with faunal and climate data from hundreds of modern European lakes. This comparison supported estimates of mean July temperature, while the accompanying pollen, sediment, organic-matter and chemical records provided evidence about forests, soil erosion, lake productivity and other environmental changes.

The oldest layers examined reflect cold conditions near the end of the last glacial period. At around 14,600 years ago, reconstructed mean July temperatures around Lake Prokoško were below 8°C. They subsequently rose by approximately 2.6°C within a comparatively short interval, reaching around 10.2°C. The reconstruction associates this warming with increased biological activity in the lake, spreading vegetation and more stable conditions in the catchment. The youngest sediments in the study cover the most recent millennium, where the chironomid community reflected not only temperature changes but also centuries of alpine grazing, greater nutrient input and the later expansion of nutrient-rich conditions.

The early warming ended abruptly when the Younger Dryas began around 12,900 years ago, the last major cooling episode at the close of the last glacial period. Estimated mean July temperatures at Lake Prokoško fell by approximately 2.3°C to about 7.9°C. Cold-water chironomid species became more abundant, while increased erosion transported more clastic material into the lake. Comparisons with reconstructions elsewhere in Europe revealed a marked spatial contrast: summer cooling of 3–4°C has been reconstructed at many Alpine lakes, whereas decreases in the Eastern and Southern Carpathians were generally less than 1°C. The Lake Prokoško estimate falls between those geographic extremes.

The researchers connect this west-to-east gradient, which becomes weaker toward the east, to oceanic and atmospheric changes in the North Atlantic region. For the Carpathian Basin, the contrast illustrates that the same large-scale climatic event can produce different responses in Western, Central and Eastern Europe. Lake Prokoško consequently provides a regional reference point for examining how the magnitude of a shared climate signal varied geographically. The researchers also emphasize that alpine lakes respond sensitively to relatively small temperature changes: variations in ice-cover duration, water stratification, oxygen content and biological activity can accompany those changes, making small mountain lakes useful environmental archives.

Warming resumed at the end of the Younger Dryas. Between approximately 11,800 and 11,400 years ago, reconstructed mean July temperatures increased by around 2.9°C. By about 10,500 years ago, they may have reached approximately 12.6°C. The lake became more productive, its ice-free season lengthened, and closed-canopy forests developed in the catchment, reducing erosion. Temperatures did not remain constant throughout the Holocene. Around 6,800 years ago, reconstructed mean July temperatures may have reached approximately 14°C, meaning that some summers around Lake Prokoško were warmer than those experienced today. The researchers distinguish this Middle Holocene warmth from present-day warming: the earlier conditions were mainly seasonal and driven by gradual changes in Earth’s orbital parameters that increased Northern Hemisphere summer insolation, whereas current warming is global, year-round, more rapid and primarily associated with human-caused greenhouse gas emissions.

A cooling trend began around 6,000 to 5,500 years ago during the Neoglacial transition toward a cooler Late Holocene. Reconstructed mean July temperatures fell from approximately 14°C to around 12.8°C, then to 11.8°C by about 5,670 years ago. Pollen evidence indicates that people were altering the landscape around the lake by the end of the Neolithic, approximately 6,000 years ago. Plants associated with grazing and open habitats became more common, followed later by more intensive forest use and the expansion of open areas. The same sediment archive therefore records both reconstructed climatic variability and the growing influence of human land use, although it does not by itself establish that human activity caused the temperature changes documented in the sequence.

Later Holocene temperatures continued to vary. Around 3,000 years ago, another significant cooling began, with mean summer temperatures falling from approximately 14.7°C to 12°C. Around 2,000 years ago, reconstructed temperatures rose during the Roman Warm Period, reaching approximately 13.3°C. Over the past millennium, centuries of alpine grazing opened the surrounding landscape and increased the nutrient load entering Lake Prokoško. The chironomid community changed significantly around 700 years ago, and species preferring more nutrient-rich waters became increasingly common over the following 500 years. Together, the two studies show that the lake’s fossil and sediment record captures environmental responses shaped by both regional climate change and local human transformation, while also demonstrating that estimates for individual periods remain reconstructions derived from sediment proxies and modern comparative data.

Subject of Research: Paleoclimate reconstruction of summer temperature variability in the Western Balkans

Article Title: Where three climate zones meet

Article References: Where three climate zones meet. Original publication (Bibliographic details unavailable.)

Image Credits: AI Generated

DOI: Not provided

Keywords: Lake Prokoško, Western Balkans, summer temperatures, paleoclimate, chironomid fossils, Younger Dryas, Holocene, climate reconstruction, land use, alpine lake, three, climate

Cardiovascular magnetic resonance measurements identified a hemodynamic pattern associated with death or heart-transplant referral or listing in people with Fontan circulation, according to a retrospective study of 182 patients followed at a moderate-altitude center. Patients who later experienced the composite outcome had a lower superior vena cava flow index than those who did not. In time-to-event analysis, each 0.1-liter-per-minute-per-square-meter increase in the indexed flow was associated with a 30% lower hazard of the outcome.

The association remained in an exploratory model that also included ventricular ejection fraction, but the researchers said the estimate requires prospective, multicenter validation before clinical application. The cohort comprised people who had undergone Fontan palliation between 1999 and 2021 at a tertiary institution approximately 5,118 feet above sea level. Fontan circulation passively directs systemic venous blood into the pulmonary arteries without the support of a sub-pulmonary ventricle.

Eligible participants had a clinically indicated CMR examination at least five years after Fontan completion, a threshold selected to match the center’s routine surveillance practice. For patients with multiple examinations, investigators used the last CMR obtained before an outcome or censoring. Most participants, 173 of 182, or 95%, had an extracardiac conduit Fontan circulation, and 76, or 42%, underwent a Damus–Kaye–Stansel anastomosis.

At CMR, the median body surface area was 1.43 square meters, with an interquartile range of 1.16 to 1.69 square meters. The median age at Fontan completion was 3.2 years, and the median interval between surgery and imaging was 10.9 years. Median follow-up after CMR was 4.7 years, while participants’ median home elevation was 5,221 feet above sea level.

Hypoplastic left heart syndrome was the most common underlying diagnosis, accounting for 35% of the cohort, followed by tricuspid atresia at 30%. The systemic ventricle was left-dominant in 53% and right-dominant in 47%. Magnetic resonance examinations were performed on 1.5- or 3.0-tesla scanners, with cine imaging used to assess ventricular function and phase-contrast sequences used to measure blood flow.

The primary endpoint combined death with referral or listing for heart transplantation. Fourteen patients, or 7.7% of the cohort, met that endpoint during follow-up: two died and 12 were referred or listed for transplantation. Among patients who experienced the outcome, the median time from CMR to the first qualifying event was 1.2 years, with an interquartile range of 0.5 to 2.5 years.

The median superior vena cava flow index was 0.54 liters per minute per square meter among patients with the primary outcome, compared with 0.82 liters per minute per square meter among those without it; the difference was statistically significant, with a p-value of 0.011. The superior vena cava-to-ascending-aorta flow ratio was also lower in the event group, with medians of 0.22 and 0.30, respectively. Several other CMR flow measures did not differ significantly between patients with and without the primary outcome.

These included flow indices in the ascending aorta, right pulmonary artery, left pulmonary artery and inferior vena cava, as well as calculated systemic-to-pulmonary collateral flow. Receiver operating characteristic analysis indicated that superior vena cava flow index discriminated between patients who met the endpoint and those who did not with an area under the curve of 0.74 and a 95% confidence interval of 0.56 to 0.92. A data-derived threshold of 0.66 liters per minute per square meter, selected using the Youden index, yielded 70% sensitivity and 75% specificity.

Kaplan–Meier curves showed significantly poorer event-free survival among patients below that threshold. Because the threshold and discrimination measures came from the same cohort, they are exploratory rather than externally validated clinical cutoffs. Univariable Cox proportional hazards regression found a hazard ratio of 0.70 for each 0.1-liter-per-minute-per-square-meter increase in superior vena cava flow index, with a 95% confidence interval of 0.50 to 0.92 and a p-value of 0.008.

Right-dominant ventricular morphology was also associated with a higher hazard than left-ventricular dominance, with a hazard ratio of 3.21, a 95% confidence interval of 1.00 to 10.29 and a p-value of 0.049. The investigators constructed a two-variable Cox model containing superior vena cava flow index and ejection fraction. Each one-percentage-point increase in ejection fraction was associated with an adjusted hazard ratio of 0.92, with a 95% confidence interval of 0.86 to 0.97.

Because only 14 primary events occurred, the multivariable analysis was deliberately restricted and was intended to test whether the flow association persisted beyond ventricular function rather than develop a full prediction model. Internal bootstrap analysis using 2,500 resamples produced a median hazard ratio of 0.71 for superior vena cava flow index and 0.92 for ejection fraction, close to the original adjusted estimates. Collinearity between the two variables was negligible, with a Spearman absolute correlation below 0.1, an R-squared value of 0.008 and a variance inflation factor of 1.01.

Tests did not indicate violation of the proportional-hazards assumption. Ventricular measures also differed according to morphology: in the right-dominant subgroup, patients with events had larger indexed ventricular volumes and lower ejection fraction than those without events, whereas comparable differences were not statistically significant in the smaller left-dominant event subgroup. The study does not establish why lower superior vena cava flow was associated with poorer outcomes.

One proposed explanation is that chronic hypobaric exposure at moderate altitude promotes pulmonary vasoconstriction and raises pulmonary vascular resistance, potentially restricting passive flow through the Fontan pathway. However, pulmonary vascular resistance was not directly measured, and the cohort included no sea-level comparator, so the study cannot determine whether altitude caused the observed hemodynamic pattern. Other possible contributors include anatomical differences in the superior vena cava, systemic venovenous collateral vessels that divert blood around the pulmonary vascular bed, and differences in preload or single-ventricle filling.

The findings therefore associate reduced indexed flow with an unfavorable hemodynamic state rather than demonstrate a specific underlying mechanism. Important limitations constrain the results. The retrospective, single-center design creates the possibility of selection bias, and clinically performed CMR examinations were not acquired at standardized surveillance intervals.

Selecting the last scan before an outcome or censoring may introduce reverse-causation bias because patients approaching clinical deterioration could have been imaged nearer the event. Clinically relevant potential confounders—including functional class, cardiopulmonary exercise capacity, resting oxygen saturation, natriuretic peptide levels, catheterization-derived Fontan pressure and pulmonary vascular resistance, pulmonary vasodilator therapy, arrhythmia burden and the severity of liver disease—were unavailable or not incorporated. The small number of events also leaves the multivariable estimates vulnerable to overfitting despite the deliberately parsimonious model and bootstrap resampling.

Furthermore, the predominance of fenestrated extracardiac conduit Fontan circulation limits generalizability to other surgical configurations. The results position superior vena cava flow index as a candidate prognostic marker that may complement ventricular size and ejection fraction in longitudinal assessment of Fontan circulation, but they do not establish a clinical measurement rule or treatment strategy. Prospective, multicenter studies comparing cohorts across elevations would be needed to test the temporal relationship, determine whether altitude modifies the association, and establish external validity.

The authors also identified four-dimensional flow CMR as a possible tool for characterizing three-dimensional flow patterns and energy loss within the Fontan pathway. Further work could compare imaging signatures with exercise physiology, biomarkers of end-organ dysfunction and pulmonary vascular imaging. Until those studies are completed, the association between reduced superior vena cava flow and adverse outcomes should be regarded as an exploratory finding that requires independent validation.

Subject of Research: Association between CMR-derived blood flow and adverse outcomes in people with Fontan circulation

Article Title: Cardiovascular magnetic resonance–derived hemodynamics predict adverse outcomes after Fontan palliation

Article References: Platnick, C., Frank, B., Romanowicz, J., Gonzalez De Alba, C., Chase, M., Umer, A., Chaudhuri, N. R., Awori, J., Chauhan, D., Mascio, C. E., Udassi, J. P., & Hedjazi Moghari, M. (2026). Cardiovascular magnetic resonance–derived hemodynamics predict adverse outcomes after Fontan palliation. Frontiers in Cardiovascular Medicine, 13, Article 1937933. https://doi.org/10.3389/fcvm.2026.1937933

Image Credits: AI Generated

DOI: 10.3389/fcvm.2026.1937933

Keywords: Fontan circulation, cardiovascular magnetic resonance, superior vena cava flow, heart transplantation, congenital heart disease, risk stratification, ventricular function, moderate altitude, flow quantification, retrospective cohort, Cardiovascular, magnetic

Apple Music unveiled a new brand identity on October 21, combining a revised wordmark, a sonic signature, and moving visuals shaped through physical experiments with sound. The project brings together Apple Music and TBWA\Media Arts Lab, with an original composition by British producer Fred again.. and NEST Acoustics providing the musical foundation.

The concept is described as “made by sound.” Rather than treating music as a soundtrack added after the visuals were finished, the creative process used audio to generate movement that could be filmed and incorporated into the identity.

The reveal explains how Apple Music intends to connect its visual and audio branding across different settings. The wordmark, musical-note symbol, filmed sequences, and short composition each contribute to that identity, while the rollout determines where audiences will encounter them.

Sound Becomes Part of the Image

According to Wallpaper’s account of the project, the team played musical notes through a transducer, which converts audio signals into physical vibrations. Those vibrations moved a shallow bath of mineral oil, producing ripples and shifting refractions.

The resulting patterns were captured on camera and became material for the visual design. Fred again.. and NEST Acoustics also developed a short composition that serves as the identity’s sonic signature.

The experimentation also influenced the composition. Fast Company reports that too many notes, or notes pitched too high, created excessive movement and made the image difficult to read. Those tests helped establish constraints for the musicians as they developed the sonic signature.

The result came from adjusting sound and image together. The team could observe how a musical choice changed the liquid’s movement, then refine the composition with the visual response in mind.

A Heavier Wordmark Joins the Moving Visuals

The refresh also changes the service’s typography. Wallpaper describes a customized version of Apple’s SF Pro typeface, with bold, lowercase lettering accompanying the Apple symbol.

The musical-note icon is another component of the system. Together, the lettering, symbol, motion, and sound create several ways to identify Apple Music, depending on the setting.

Those distinctions help explain why a single screenshot cannot represent the whole project. An app icon must remain recognizable at a small size. A video sequence can use time, movement, lighting, and audio to establish a different impression.

The new identity therefore needs to be considered both as a collection of individual elements and as a coordinated presentation. Someone may prefer the animated treatment while responding differently to the static lettering; those reactions concern different parts of the same design.

Introducing a new identity for Apple Music, physically shaped by an original composition from @fredagainagain1 and NEST Acoustics. https://t.co/LFXLIfexPL

— Apple Music (@AppleMusic) October 21, 2026

The Film Shows the Physical Production Process

A companion film documents the work behind the identity. iClarified’s coverage describes a 78-second sequence moving between the practical setup and the finished visuals.

The team submerged acrylic versions of the musical-note symbol and wordmark in mineral oil. Fast Company reports that the oil was selected for its viscosity, helping create the appearance of glass rippling under sound. Filming the moving liquid and refracted light produced the distortions seen in the finished sequences.

The behind-the-scenes approach makes the production method visible. It gives viewers something specific to examine: the relationship between a musical composition, a physical response, and the image recorded by the camera.

It also provides a useful distinction between inspiration and execution. Saying that a design is inspired by music is broad. Showing sound physically influencing the material being filmed explains how that idea entered the finished work.

The Rollout Extends Beyond the App Icon

Fast Company’s reporting identifies Apple Music, TBWA\Media Arts Lab, Fred again.., and NEST Acoustics as collaborators. It says the identity will begin appearing across original content and event programming this week, with marketing, product, and other experiences following later.

That describes a staged introduction rather than a single moment when every Apple Music surface changes. Viewers may encounter the new presentation in promotional or editorial material before seeing it consistently elsewhere.

The announcement is about branding. It does not, by itself, establish changes to subscription plans, playback quality, recommendations, or the music catalog. Those product details require separate announcements.

A Musical Idea Gives the Refresh Its Focus

The strongest part of the project is the clear relationship between its subject and its method. A service built around listening has used a composition to influence its visual identity, giving the sound and moving image a shared origin.

How successfully the elements work across everyday settings will become clearer as the rollout progresses. For now, the reveal offers a concrete account of creative collaboration—and a reason to look beyond the icon when assessing Apple Music’s new appearance.

The post Apple Music’s New Identity Turns Sound Into Moving Images appeared first on AppleMagazine.

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As spotted by Hidde Collee, the Apple Music page on Apple's website now has the updated branding that Apple officially introduced earlier today.


Apple Music has a new black-and-white logo and app icon, with Apple doing away with the red color scheme that it previously used for the streaming music service.

In a YouTube video released earlier today, Apple showed how the new Apple Music visuals were "made by sound." The video showed off the new Apple Music logo with colorful animations, despite the new Apple Music app icon in the iOS 27.2 beta having a more basic black-and-white design. It is unclear if a splash of color will be added later.


Apple Music has also received a distinct font with a modern, impactful aesthetic.

The rebrand will roll out with Apple's next software releases, including iOS 27.2 and macOS 27.2. The updates are expected to be released next week.
This article, "Apple Music's New Look is Now Live on Apple's Website" first appeared on MacRumors.com

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The spending has hurt the Silicon Valley giant’s cash flow, which turned negative. Meta said it would issue a new class of stock to help it raise more money.

Just 9 months after raising an $180 million seed round, Flapping Airplanes has landed $1 billion Series A for its mission to build AI models "without ingesting half the internet."

A deal would consolidate Elon Musk’s holdings in rockets, cars and artificial intelligence into a company worth well over $3 trillion.

Anthropic today introduced Claude Duet, its answer to Meta's Muse agent and OpenAI's Dots agent. Like Dots and Muse, it is a proactive agent that "reaches out before you ask."


Claude Duet connects to your apps and suggests things that need your attention. It completes tasks and can work in the cloud without local access to a computer. As with Muse and Dots, Duet has a virtual machine with its own browser to complete tasks.

Anthropic says it built Duet for professionals and small business owners with too much to track, as those are the people most likely to find it helpful.

Duet is built around Opus 5.5. It sends a short brief each morning on important items from connected apps, then checks apps every few hours and sends an alert when something needs attention. It can complete simple administrative tasks or more complex tasks like building web apps. While the agent works on its own, it will get user approval before it takes actions like sending a message, making a payment, signing a document, or deleting a file.


It incorporates memory, skills, and connected apps from a Claude account, so there isn't much setup involved. Interactions happen in one ongoing thread instead of across different conversations.

Claude Duet does not see passwords or logins when given access to accounts, and it has a dedicated classifier and safety system prompt that checks each message and guards against sensitive information leaks.

Claude Duet is a standalone product that's available in a research preview right now with access granted via waitlist. It's limited to Pro and Max subscribers in the United States, and can be used via the web or a standalone Duet iOS app. Duet uses your existing Claude plan limits, and its background checks will count toward them.
This article, "Anthropic Launches Claude Duet, a Proactive AI Agent" first appeared on MacRumors.com

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The tool, which is not yet widely available, will compete with OpenAI’s dots and Meta’s Muse. It is built for work and not personal errands.

Startup Recursive has released Flint, a free, laptop-sized coding model built largely by its own AI research system, as an early test of AI that improves itself.

Automattic has begun laying off employees across multiple teams, including WordPress.com and its enterprise business, following a board shakeup and a series of executive departures. Sources say more cuts could follow as the company looks to improve its finances.