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Programmable design of functional proteins from natural language

By: Fengyuan Dai · Shiyang You · Yudian Zhu · Yuan Gao · Lihao Fu · Xibin Zhou · Jin Su · Chentong Wang · Yuliang Fan · Qingsong Tan · Xiaoxiao Ma · Xianjun Deng · Letong Yu · Hui Qian · Yan He · Yitao Ke · Zhe Zhang · Chenchen Han · Xing Chang · Liangzhen Zheng · Sheng Wang · Yuan Ji · Kexin Hao · Longxing Cao · Yajie Wang · Anping Zeng · Shunzhi Wang · Chunjun Zhan · Jing Zhao · Tong Si · Jianming Liu · Hongyuan Lu · Fajie Yuan

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Plastoglobules compartmentalize nitrogen assimilation in maize

Nature

By: Di Chen · Lulu Gao · Shujun Li · Yiqiu Cheng · Xiaoxian Wu · Wenhao Li · Jinman Zhang · Xueling Fu · Pan Xiang · Lu Sun · Zhiteng Chen · Hua Zhang · Youliang Li · Shiqi Luo · Chong You · Linhan Sun · Xing Huang · Yidong Zhu · Xing Zeng · Wenqin Wang · Yan He · Haihai Wang · Yu Zhang · Xuewei Chen · Yongrui Wu · Yongcai Huang

3 June 2026 at 01:00

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10610-8

Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.