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Programmable design of functional proteins from natural language

✇Nature
By: Fengyuan Dai · Shiyang You · Yudian Zhu · Yuan Gao · Lihao Fu · Xibin Zhou · Jin Su · Chentong Wang · Yuliang Fan · Qingsong Tan · Xiaoxiao Ma · Xianjun Deng · Letong Yu · Hui Qian · Yan He · Yitao Ke · Zhe Zhang · Chenchen Han · Xing Chang · Liangzhen Zheng · Sheng Wang · Yuan Ji · Kexin Hao · Longxing Cao · Yajie Wang · Anping Zeng · Shunzhi Wang · Chunjun Zhan · Jing Zhao · Tong Si · Jianming Liu · Hongyuan Lu · Fajie Yuan

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.
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Structural basis of the RNA-editing cascade in trypanosome mitochondria

✇Nature
By: Yun-Tao Liu · Andres F. Vacas · Jonathan Jih · Xiaojing Zhao · Clinton Yu · Jane K. J. Lee · Takuma Suematsu · Md Solayman · Hong Wang · Xiaorong Wang · Lan Huang · Liye Zhang · Inna Aphasizheva · Z. Hong Zhou · Ruslan Aphasizhev

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-x

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.
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20.46% efficient organic solar cells with concurrent voltage enhancement and thermal stability enabled by crystallization-kinetics-controlled morphology

✇RSC - Energy Environment
By: Anhai Liang · Chunliang Li · Bosen Zou · Sein Chung · Byeongjin Kim · Yongjoon Cho · Jiancheng Zhong · Jingjing Zhao · Lixing Tan · Guangquan Zhang · Xin Li · Wuning Wei · Kilwon Cho · He Yan · Zhipeng Kan

Energy Environ. Sci., 2026, 19,3487-3499
DOI: 10.1039/D6EE01250G, Paper
Anhai Liang, Chunliang Li, Bosen Zou, Sein Chung, Byeongjin Kim, Yongjoon Cho, Jiancheng Zhong, Jingjing Zhao, Lixing Tan, Guangquan Zhang, Xin Li, Wuning Wei, Kilwon Cho, He Yan, Zhipeng Kan
Incorporating BTP-FCIO extends the acceptor phase nucleation time from 132 ms to 199 ms and enhances the efficiency to 20.46%. This ternary strategy demonstrates consistent effectiveness across multiple representative Y-series acceptors.
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