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Scientists discover migration-mediated mechanism enabling bacteria-virus coexistence

Bacteria and the viruses that infect themโ€”known as phagesโ€”coexist in soils, oceans and living organisms. Scientists have long thought this coexistence reflects a microscopic version of an evolutionary arms race: As parasites and hosts continually adapt to one another, both evolve ways to survive. But a joint study by researchers at the University of Maryland and the University of Exeter shows different pathways to coexistence.

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Scientists discover migration-mediated mechanism enabling bacteria-virus coexistence

Bacteria and the viruses that infect themโ€”known as phagesโ€”coexist in soils, oceans and living organisms. Scientists have long thought this coexistence reflects a microscopic version of an evolutionary arms race: As parasites and hosts continually adapt to one another, both evolve ways to survive. But a joint study by researchers at the University of Maryland and the University of Exeter shows different pathways to coexistence.

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Device simulates natural conditions to grow biofilms and test their antibiotic susceptibility more accurately

Biofilms are complex microbial communities that adhere to a surface and encase themselves in a viscous matrix they produce. This structure protects bacteria from antibiotics and the immune system far more effectively than if they lived in a free-floating state, making biofilms one of the most common causes of hard-to-treat chronic infectionsโ€”such as respiratory infections in people with cystic fibrosis and chronic obstructive pulmonary disease (COPD), chronic wounds, or infections associated with catheters and prosthetic devices. Added to this is the global rise in antibiotic resistance, which makes it increasingly urgent to have tools capable of predicting which treatment will work in each case.

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An unusual bacterium that penetrates and lives inside human cells may offer a new drug target

Research underway in the lab of Rebecca Alexander, a professor in Wake Forest University's Department of Chemistry, is shedding light on an unusual human bacterium, Mycoplasma penetrans. Alexander's work to understand how and why this unique pathogen acts as it does could one day lead to new classes of drugs that better target illnesses associated with this particular pathogen, as well as others that act similarly.

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A cellular threshold can determine whether herpesvirus becomes active or lies dormant

During the COVID-19 pandemic, we wore masks and kept 2 meters (6.6 feet) apart in an effort to reduce the spread of the tiny droplets we release into the air with every breath, conversation or cough. The main goal was to reduce the number of virus particlesโ€”known as virionsโ€”to which we were exposed. For each virus, a person must be exposed to a minimum infectious dose to develop disease, and in many cases, the larger the dose, the more severe the illness.

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A 'wholistic' view of cellular communication across an entire animal

It can't be heard, but different parts of the human body are in constant conversation, communicating to keep the entire system running efficiently. For biologists, being able to listen in on this discussion is a long-sought-after goal. Over the years, researchers have caught snippets of these exchanges, but the complete dialogue has remained out of reach.

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A 'wholistic' view of cellular communication across an entire animal

It can't be heard, but different parts of the human body are in constant conversation, communicating to keep the entire system running efficiently. For biologists, being able to listen in on this discussion is a long-sought-after goal. Over the years, researchers have caught snippets of these exchanges, but the complete dialogue has remained out of reach.

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Biologists find a hidden weak spot in how bacteria build the tails they use to move

New research from Indiana University has uncovered a previously unknown vulnerability in how bacteria build the whip-like tails they use to move. The researchers found that building these tails can put stress on the protective wall surrounding a bacterial cell and uncovered systems bacteria use to keep that stress from becoming destructive.

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Local microbes persist in wine despite commercial yeast

A new study has demonstrated that regional microbial imprints can remain detectable under commercial winemaking conditions. The research, appearing in Applied and Environmental Microbiology, shows that inoculated fermentations do not "override" native microbial diversity and that vineyard management and environmental conditions affect wine quality. The study helps explain why wines from different regions taste distinct even when made with similar techniques and supports regional flavors and branding.

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Unlocking the past: New method helps gain insights into old tissues

A book sits atop a table. Although it's closed, its title, "Encyclopedia of Human Tissue," promises untold secrets. Perhaps with this book, you can learn about different cell types and what they look like under normal conditions or conditions of disease. Maybe you can learn how gene expression differs in the cells of younger and older people, or whether different patients' cells respond differently to the same treatments.

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