New active ingredients for drugs to treat infections, cancer or other serious diseases are often based on substances originally discovered in microorganisms, plants or other living organisms. Producing or improving such active ingredients in a targeted manner using microorganisms is often challenging because the underlying biological processes are extremely complex.
New active ingredients for drugs to treat infections, cancer or other serious diseases are often based on substances originally discovered in microorganisms, plants or other living organisms. Producing or improving such active ingredients in a targeted manner using microorganisms is often challenging because the underlying biological processes are extremely complex.
Where did it start? How did it grow complex? Why did it get big? Three moments in Earth’s early history when evolution suddenly, inexplicably turned up the dial.
A new approach that changes just one atom in plastic-degrading enzymes could help make them more efficient while maintaining their stability, according to new research from The Australian National University published in Angewandte Chemie International Edition.
A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.
A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.
The development of cooking was a major milestone in the evolution of human civilization because it made food easier to digest and more energy-efficient. Heating food can also kill harmful pathogens and make certain foods taste better. Overcooking, on the other hand, can have adverse effects, particularly on proteins.
The biopolymer lignin—one of the most important carbon reservoirs in plants and soils—not only decays through fungi or bacteria but can also be chemically attacked by iron linked to reactive oxygen species, without the involvement of microorganisms. When this happens, lignin is converted into methanol and subsequently into formaldehyde. That is shown by a study conducted at Heidelberg University's Institute of Earth Sciences.
Ancient teeth suggest humans were using psychoactive betel nuts 25,000 years ago, pushing the history of habitual drug use deep into the Ice Age. Archaeologists from Griffith University have found evidence suggesting that humans were using mind-altering substances far earlier than previously believed. The research team, led by Professor Adam Brumm of Griffith’s Australian Research [...]
For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing rings. But there are limits to their usefulness.
For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing rings. But there are limits to their usefulness.
Life in the deep sea is under immense pressure—literally. Such extreme conditions can disrupt the delicate structures of proteins essential to life. Yet somehow, the proteins in deep-sea creatures remain functional. This raises an intriguing question: how?
Life in the deep sea is under immense pressure—literally. Such extreme conditions can disrupt the delicate structures of proteins essential to life. Yet somehow, the proteins in deep-sea creatures remain functional. This raises an intriguing question: how?
Lipid droplets in the kidneys may help cats maintain a consistent chemical “scent identity.” Scent marks can linger long after an animal has moved on, allowing urine and other chemical signals to carry information across both distance and time. Yet the molecules responsible for odor do not remain unchanged. They evaporate, break down, and shift [...]
Researchers from the Singapore-MIT Alliance for Research & Technology's (SMART) Antimicrobial Resistance (AMR) interdisciplinary research group, alongside collaborators from Massachusetts Institute of Technology (MIT), Nanyang Technological University (NTU Singapore), and institutions in the United States, Poland and France, have discovered aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress.
For more than seven decades, phosphorus has represented one of the great paradoxes in the study of the origin of life. This element, indispensable for the existence of living beings as we know them, forms the structural backbone of DNA and RNA, allows cells to store and transfer energy through the molecule adenosine triphosphate (ATP), […]
Researchers from the Manchester Institute of Biotechnology, including Dr. Zachary Birch-Price and professor Anthony Green, have developed a new family of engineered enzymes that can create several different types of chemical bonds used to build complex molecules. This work demonstrates how artificial enzymes can be adapted to carry out a broad range of carbon-carbon (C-C) and carbon-nitrogen (C-N) bond-forming reactions with high selectivity, offering new possibilities for biocatalysis.
Researchers from the Manchester Institute of Biotechnology, including Dr. Zachary Birch-Price and professor Anthony Green, have developed a new family of engineered enzymes that can create several different types of chemical bonds used to build complex molecules. This work demonstrates how artificial enzymes can be adapted to carry out a broad range of carbon-carbon (C-C) and carbon-nitrogen (C-N) bond-forming reactions with high selectivity, offering new possibilities for biocatalysis.
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