GRP75-dependent SIMPA mediates inter-organellar quality control

By: Fan Yu · Lingyu Jiang · Hanyu Liu · Song Yang · Yuan Yuan · Hongzhen Jin · Jinming Liu · Xi Liu · Yu Dong · Dongfeng Ren · Jie Kang · Yan Huang · Qi Meng · Feng Bai · Yanjun Li · Shuoguo Li · Huadong Liu · Wei Zhao · Jia Xiao · Quan Chen

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Sexual dimorphism in epidermal stem cell dynamics

Nature

By: Dan Engelman · Joel Hochstetter · Anaïs Bauduin · Sagar Patil · Marta Valenti · Yura Song · Qiuyu Lian · Annagiada Toniolo · Mohammad Ghiasloo · Nordin Bansaccal · Anne-Lise Delaunois · Mélanie Liagre · Michele De Luca · Esther Hoste · Laura De Rosa · Yulia Shwartz · Benjamin D. Simons · Cédric Blanpain

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11159-2

Long-term live imaging of adult mouse ear skin reveals sex-specific differences in the clonal dynamics of epidermal stem cells and transit-amplifying cells during homeostasis.

A dependency map enhanced with next-generation 3D cancer models

Nature

By: James V. Neiswender · Samuel Maffa · Lisa Brenan · Dina ElHarouni · Yejie Yun · Isabella Boyle · Kirsty Wienand · Haider Inam · Tate Bertea · Ashley Anderson · Megan Wong · Matias Enriquez · Evan Lenz · Beatriz Villafranca · Nora Shanks · Mary Hager · Nia Lloyd · Hannah Shadmany · Sarah J. Wie · Harry Liang · Konnor Yunghans · Xiaomeng Zhang · Lauren Golden · Hannah Harris · Serena Day · Philip Montgomery · Samantha Stokes · Ross M. Giglio · Cynthia Hajal · James R. Whittle · Guadalupe Garcia · Caitlin E. Mills · Mehdi Touat · Kristine Pelton · Hongyu Li · Prem Sai Prabhakar · Sonja Herter · Zoe Hoffmann Kamrat · Dan Gui · Julien Dilly · Chen Khuan Wong · Jimmy A. Guo · Sangita Pal · Yossef Baidi · Ryan Johnston · Daniel D. Brown · Sonam Bhatia · Peter S. Winter · Srivatsan Raghavan · Rameen Beroukhim · Eva Colas · David L. Spector · Adam J. Bass · Peter K. Sorger · Yu Chen · Sarah J. Hill · Steffi Oesterreich · Adrian V. Lee · Himisha Beltran · Jesse S. Boehm · Yuen-Yi Tseng · David E. Root · William C. Hahn · Andrew J. Aguirre · Catarina D. Campbell · Keith L. Ligon · Jo

5 August 2026 at 01:00

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10843-7

Integration of genome-scale CRISPR screening data from traditional cell lines and next-generation cancer models expands the representation of tumour subtypes and genomic alterations in The Cancer Dependency Map.