Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10945-2

Author Correction: A ductile solid electrolyte interphase for solid-state batteries

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10686-2

Liver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen production.

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10646-w

A co-optimized AI hardware–software system using resistive-memory computing improves energy efficiency and parallelism for sparse signal reconstruction in imaging and three-dimensional vision applications.