Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10970-1

Thermally evaporated perovskite/silicon tandems via formamidinium eutectic

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10945-2

Author Correction: A ductile solid electrolyte interphase for solid-state batteries

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10801-3

A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10686-2

Liver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen production.

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10646-w

A co-optimized AI hardware–software system using resistive-memory computing improves energy efficiency and parallelism for sparse signal reconstruction in imaging and three-dimensional vision applications.