GRP75-dependent SIMPA mediates inter-organellar quality control

By: Fan Yu · Lingyu Jiang · Hanyu Liu · Song Yang · Yuan Yuan · Hongzhen Jin · Jinming Liu · Xi Liu · Yu Dong · Dongfeng Ren · Jie Kang · Yan Huang · Qi Meng · Feng Bai · Yanjun Li · Shuoguo Li · Huadong Liu · Wei Zhao · Jia Xiao · Quan Chen

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Structural basis of ligand recognition and gating in mosquito IRs

Nature

By: Li Xu · Xin Wang · Xuebo Quan · Stephen T. Ferguson · Dong Liu · Jiawei Chen · Sai Wang · Simin Liang · Gaoxingyu Huang · Kai Huang · Feng Liu · Xiaojing Pan

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11239-3

Structural basis of ligand recognition and gating in mosquito IRs

Competing mechanisms toughen bcc binary and medium-entropy alloys at 20 K

Nature

By: David H. Cook · Xiaoyu Chen · Michael O’Leary · Satish Rao · Wenqing Wang · Calvin H. Belcher · Madelyn Payne · Pedro Borges · Tung Lik Lee · Arun Devaraj · Mark Asta · Enrique J. Lavernia · Diran Apelian · Andrew M. Minor · Dong Liu · Punit Kumar · Robert O. Ritchie

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11065-7

The mechanical properties of medium-entropy alloys at 20 K show a plateau in tensile yield strength and fracture toughness as a function of temperature, with no apparent ductile-to-brittle transition.

Reading view