Nature, Published online: 23 October 2026; doi:10.1038/d41586-026-03395-3

Andrew Robinson reviews five of the best science picks.

Nature, Published online: 23 October 2026; doi:10.1038/d41586-026-03417-0

Long-awaited results from phase III trial show a huge benefit in treating treatment-resistant melanoma.

Nature, Published online: 22 October 2026; doi:10.1038/d41586-026-03414-3

From underwater speakers to growing super-corals, scientists battle to save reefs around the world.

Nature, Published online: 22 October 2026; doi:10.1038/d41586-026-03438-9

See what gave Denisovans their distinct look. Plus, a vaccine trial for Ebola could kick off this week in the Democratic Republic of the Congo and what makes a great climate graphic.

Nature, Published online: 22 October 2026; doi:10.1038/s41586-026-11312-x

Current-Driven Molecular Machine with Rotation-Enhanced Conductance

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11317-6

De novo design of enantioselective artificial metalloenzyme photocatalysts

Nature, Published online: 21 October 2026; doi:10.1038/d41586-026-03376-6

Experiment shows how these ecosystems could protect coastlines from huge storms — plus, new evidence hints at what Denisovans might have looked like.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11252-6

Author Correction: Catalyst-free, microdroplet-mediated waste plastic conversion to diacids

Nature, Published online: 21 October 2026; doi:10.1038/d41586-026-03342-2

Physicists trap and cool down positron for months to measure its ‘magnetic moment’ with extraordinary precision.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnostic framework is proposed to detect these injuries earlier, guide personalized immunosuppression and inform future gene editing strategies.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11145-8

Salt marsh platforms resist erosion under extreme waves, but vegetation damage reduces wave attenuation; substantial wave attenuation by vegetation is mainly limited to low-energy marsh coasts with waves below 1 m.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11183-2

The use of zeolites with an appropriate pore structure combined with a high CO/olefin ratio is shown to catalyse olefin carbonylation and produce primary and secondary carboxylic acids as the main products.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11152-9

A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x

Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11179-y

An environment-regulated state is identified across multiple cell types at the root tip, revealing a shared dichotomy between cells with and without this state.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11186-z

CD51+ astrocytes promote synapse formation in the developing cortex, circuit plasticity in the hippocampus and circuit remodelling after stroke.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4

Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11184-1

The structure of PCDH1 bound to the ANDV spike defines the structural determinants of hantavirus–receptor recognition.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.