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Normal view

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Programmable design of functional proteins from natural language

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Managing the impacts of EU electric vehicle import tariffs

Nature Energy, Published online: 10 July 2026; doi:10.1038/s41560-026-02102-w

EU import tariffs on battery electric vehicles may not substantially hinder the overall electrification process but may substantially reduce adoption in vulnerable markets. These findings highlight the uneven implications of broad trade interventions and underscore the importance of complementary policies to support a resilient and inclusive transition.

Efficient and accurate neural-field reconstruction using resistive memory

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10646-w

A co-optimized AI hardware–software system using resistive-memory computing improves energy efficiency and parallelism for sparse signal reconstruction in imaging and three-dimensional vision applications.

Unravelling the anion-dominated interfacial structure of hybrid solid electrolytes via ssNMR

Energy Environ. Sci., 2026, 19,3667-3677
DOI: 10.1039/D6EE00543H, Paper
Yuhang Li, Likun Chen, Shengnan Zhang, Yubin Li, Junwei Liang, Yuetao Ma, Ke Yang, Zhuo Han, Guanyou Xiao, Longxiang Yu, Chenjie Lou, Yan-Bing He, Feiyu Kang, Ming Liu
The TCM− anion prevents the PS43− to P2S74− phase transition via weak interactions with LPSC. This maintains the PS43−-based boundaries in HSE-LiTCM, ensuring rapid Li+ transport and high conductivity.
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