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A single archaeon couples long-chain fatty acid oxidation to methanogenesis

By: Yue Yi Β· Zuorong Cao Β· Kejia Wu Β· Hengwu Ding Β· Lin Fu Β· Wenyi Gao Β· Ling Li Β· Lei Zhou Β· Zhuo Zhou Β· Lirong Dai Β· Yahai Lu Β· Lei Cheng
21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11207-x

Methanoglobus dolicholipophagus AA-75 is a thermophilic archaeon isolated from a Chinese petroleum reservoir that converts methanol into methane, carbon dioxide and acetate, and uses saturated and unsaturated fatty acids to produce methane.

Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
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