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Received — 21 October 2026 ⏭

Programmable design of functional proteins from natural language

✇Nature
By: Fengyuan Dai · Shiyang You · Yudian Zhu · Yuan Gao · Lihao Fu · Xibin Zhou · Jin Su · Chentong Wang · Yuliang Fan · Qingsong Tan · Xiaoxiao Ma · Xianjun Deng · Letong Yu · Hui Qian · Yan He · Yitao Ke · Zhe Zhang · Chenchen Han · Xing Chang · Liangzhen Zheng · Sheng Wang · Yuan Ji · Kexin Hao · Longxing Cao · Yajie Wang · Anping Zeng · Shunzhi Wang · Chunjun Zhan · Jing Zhao · Tong Si · Jianming Liu · Hongyuan Lu · Fajie Yuan
21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Trade-offs between soil inorganic and organic carbon driven by multiple global environmental changes

✇Nature Geoscience
By: Tongshuo Bai · Yi Wang · Jun Deng · Yunpeng Qiu · Haotian Zhang · Steven J. Hall · Yi Zhang · Shuijin Hu
19 October 2026 at 01:00

Nature Geoscience, Published online: 19 October 2026; doi:10.1038/s41561-026-02135-6

Global environmental changes can induce contrasting responses of soil organic and inorganic carbon, according to an 8-year field experiment in a semi-arid grassland and a meta-analysis.
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