We all know exercise is good for us. It builds muscle, strengthens bones, lowers blood pressure, and boosts mood. By deciphering how movement benefits the body, researchers hope to develop medicines that can offer some of the same perks—without the workout. The idea isn’t to replace exercise but to bring its upsides to people who struggle with frailty, disability, or chronic illness. 

The sticking points

It will take a lot of experimentation to untangle the myriad pathways by which exercise promotes health. But IDing the cascade of hormones, enzymes, and other molecules related to physical activity is just the first step. Scientists need to figure out how to turn that knowledge into safe and effective drugs. That’s a tall order: More than 90% of treatments that enter human studies fail.

There are regulatory hurdles too. The FDA approves medications to treat diseases, not to enhance wellness, says Thomas Burris, a pharmacologist at the University of Florida whose work focuses on diseases that respond to exercise, like obesity, type 2 diabetes, and dementia.

The progress

There may never be a pill that delivers all the benefits of exercise, but research could lead to new medicines that mimic some aspects of working out. Scientists have already identified many important exercise-related signals and have even developed compounds to regulate them. (Some preliminary results have been so promising that doping authorities have proactively banned the compounds.) 

Burris and his colleagues are focused on a receptor that’s always switched on, even without exercise. Working out appears to boost that receptor in muscle cells, which in turn helps bolster endurance over time. Burris’s lab has spent years designing a drug that cranks up the receptor’s activity directly, and mice treated with the drug ran longer and farther than mice that weren’t. They “become marathon mice without having to do any type of exercise,” Burris says. There are even indications—also in mice—that the compound mimics some of the cognitive benefits of exercise and could help treat heart failure. Burris founded a company called Pelagos to carry the work forward into a clinical trial.

Other workout-mimicking drugs have already entered human studies. In June, the biotech firm Cambrian Bio reported that its experimental drug ATX-304 boosted metabolism and reduced liver and belly fat in people with obesity and prediabetes. It activates a metabolic switch that helps cells sense when energy supplies dip and coordinates the production of more fuel—the same switch that helps us sustain long sessions jumping rope or swimming laps. Cambrian hopes it will help people lose weight without losing muscle, a common concern with GLP-1 medicines.  

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Progress meter ………… 5

Our understanding of how exercise benefits the body is still coming into focus, and drug development is prone to failure.

Humans are far from the only species with a gift for gab, and our furry, feathered, and finned friends could have a lot to tell us. Decoding how animals communicate with one another could offer a window into the inner lives of other species and help humans realize that “animals are sentient creatures who think, who have hopes and dreams of their own,” says Con Slobodchikoff, the founder of Zoolingua, a company working on dog-to-human speech.

The sticking points

Teasing all this out is complex. To decipher howls, squeaks, and clicks, researchers must match the creatures making sounds with what’s happening around them. Prairie dogs, for example, utter a different series of yips when a coyote approaches than when a hawk is nearby. It’s painstaking work, especially for difficult-to-­observe species, like deep-diving whales or subterranean mole rats.

There are other hurdles. Many animals communicate not just through sound but through visual cues, touch, pheromones, or a combination of signals, some of which might be difficult for us to perceive. And without a multispecies Rosetta stone, it’s hard to know if translations are accurate. 

The progress

Over the past 50 years, a growing arsenal of devices has made it easier to observe the sophisticated ways animals communicate. Hydrophones at the bottom of the ocean can capture humpback whale song, and tiny wearable “biologgers” can record a bat’s every squeak. 

In the last decade, advances in AI have leveled up our ability to make sense of it all. The technology can detect different calls, distinguish which sounds belong to which animal, and spot patterns. Researchers at the Earth Species Project (ESP), a nonprofit founded in 2018 to decode animal communication, recently used machine learning to detect vocalizations of carrion crows and determine which bird made which call. 

They suspect that more advanced AI could translate critters’ chatter. Large language models like Claude and ChatGPT excel at finding relationships between words, explains Sara Keen, one of ESP’s behavioral ecologists. ESP hopes its own NatureLM—trained on human speech, music, and animal sounds—will be able to interpret the vocalizations of a variety of species. 

That promise, however, is still theoretical. Yossi Yovel, a neuroecologist at Tel Aviv University, worries that these models will put too much emphasis on acoustic similarities and make mistakes—like lumping together similar sounds that have different meanings. 

As for a two-way convo? It’s not clear when—or whether—that will happen. Still, “a lot of animals have an evolutionary structure that is similar enough that we should be able to understand what they’re saying,” Slobodchikoff says. 

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Progress meter ………… 4

Researchers have amassed heaps of data on animal communication, but they’re still trying to figure out how to decipher it all.