Nature
The anatomy of a personal health agent 21 October 2026 at 01:00

The anatomy of a personal health agent

By: A. Ali Heydari · Ken Gu · Vidya Srinivas · Hong Yu · Akshay Paruchuri · Zhihan Zhang · Yuwei Zhang · Qian He · Hamid Palangi · Nova Hammerquist · Ahmed A. Metwally · Brent Winslow · Yubin Kim · Kumar Ayush · Yuzhe Yang · Girish Narayanswamy · Maxwell A. Xu · Jake Garrison · Samuel Schmidgall · Amy Armento Lee · Jenny Vafeiadou · Ben Graef · Isaac R. Galatzer-Levy · Erik Schenck · Andrew Barakat · Javier Perez · Jacqueline Shreibati · John Hernandez · Anthony Z. Faranesh · Naghmeh Rezaei · Javier L. Prieto · Conor Heneghan · Jiening Zhan · Mark Malhotra · Shwetak Patel · Yun Liu · Tim Althoff · Xin Liu · Daniel McDuff · Xuhai Orson Xu

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11161-8

A multi-agent framework that coordinates data science, medical reasoning and health coaching over longitudinal wearable and clinical data to provide holistic personal health support is described.

Nature
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution 7 September 2026 at 01:00

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Nature

By: Zhao Feng · Xiangning Li · Yue Luo · Xin Liu · Ben Long · Tao Jiang · Xueyan Jia · Xiaowei Chen · Jie Luo · Xiaokang Chai · Zhen Wang · Miao Ren · Xin Lu · Gang Yao · Mengting Zhao · Yuxin Li · Zhixiang Liu · Hong Ni · Chuhao Dou · Shengda Bao · Shicheng Yang · Zoutao Zhang · Jiandong Zhou · Lingyi Cai · Qi Zhang · Ayizuohere Tudi · Chaozhen Tan · Zhengchao Xu · Siqi Chen · Wenxiang Ding · Wenjuan Shi · Anan Li · Hong-wei Dong · Hui Gong · Qingming Luo

7 September 2026 at 01:00

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Nature
CRISPR–Cas regulates expression of embedded anti-phage defence systems 22 July 2026 at 01:00

CRISPR–Cas regulates expression of embedded anti-phage defence systems

Nature

By: Xian Shu · Rui Wang · Xufei Zhou · Feiyue Cheng · Jiayue Ma · Zhihua Li · Xin Li · Tuozhan Wu · Aici Wu · Qiong Xue · Chao Liu · Huiwei Zhao · Xifeng Cao · Lin Wang · Shouyue Zhang · Yan Zhang · Ming Li

22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.

Nature
C-glycoside synthesis via radical cross-coupling of glycohydrazides 22 June 2026 at 01:00

C-glycoside synthesis via radical cross-coupling of glycohydrazides

Nature

By: Yinliang Guo · Yiheng Li · Benedikt Buchberger · Yixin Liu · Carla Capone · Tapas Adak · Shubham Ojha · Jasper L. Tyler · Philipp Neigenfind · Molhm Nassir · Yu Kawamata · Varinder K. Aggarwal · Phil S. Baran

22 June 2026 at 01:00

Nature, Published online: 22 June 2026; doi:10.1038/s41586-026-10807-x

C-glycoside synthesis via radical cross-coupling of glycohydrazides

Nature
Teosinte alleles enhance nitrogen assimilation and seed protein in maize 3 June 2026 at 01:00

Teosinte alleles enhance nitrogen assimilation and seed protein in maize

Nature

By: Yongcai Huang · Yidong Zhu · Yahui Cui · Guolong Shi · Xiaoxian Wu · Wenhao Li · Zhiteng Chen · Yu Zhou · Yincong Gu · Zhigui Bao · Shiqi Luo · Xingguo Wu · Ruifan Li · Jingjing Liu · Xiangjie Dai · Junxin Liu · Di Chen · Lulu Gao · Chong You · Youliang Li · Yu Zhang · Wenqin Wang · Haihai Wang · Yongrui Wu

3 June 2026 at 01:00

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10575-8

Teosinte alleles enhance nitrogen assimilation and seed protein without lowering crop yield when expressed in modern maize, providing a powerful strategy for crop improvement to meet future population demands.

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