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Normal view

Received — 21 October 2026 ⏭ Nature

GRP75-dependent SIMPA mediates inter-organellar quality control

✇Nature
By: Fan Yu · Lingyu Jiang · Hanyu Liu · Song Yang · Yuan Yuan · Hongzhen Jin · Jinming Liu · Xi Liu · Yu Dong · Dongfeng Ren · Jie Kang · Yan Huang · Qi Meng · Feng Bai · Yanjun Li · Shuoguo Li · Huadong Liu · Wei Zhao · Jia Xiao · Quan Chen
21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.
Received — 11 August 2026 ⏭ Nature

Author Correction: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

✇Nature
By: Tongwu Zhang · Wei Zhao · Christopher Wirth · Marcos Díaz-Gay · Jinhu Yin · Monia Cecati · Francesca Marchegiani · Phuc H. Hoang · Charles Leduc · Marina K. Baine · William D. Travis · Lynette M. Sholl · Philippe Joubert · Jian Sang · John P. McElderry · Michelle Antony · Alyssa Klein · Azhar Khandekar · Caleb Hartman · Jennifer Rosenbaum · Frank J. Colón-Matos · Mona Miraftab · Monjoy Saha · Olivia W. Lee · Kristine M. Jones · Neil E. Caporaso · Maria Pik Wong · Kin Chung Leung · Chao Agnes Hsiung · Chih-Yi Chen · Eric S. Edell · Jacobo Martínez Santamaría · Matthew B. Schabath · Sai S. Yendamuri · Marta Manczuk · Jolanta Lissowska · Beata Świątkowska · Anush Mukeria · Oxana Shangina · David Zaridze · Ivana Holcatova · Dana Mates · Sasa Milosavljevic · Milan Savic · Yohan Bossé · Bonnie E. Gould Rothberg · David C. Christiani · Valerie Gaborieau · Paul Brennan · Geoffrey Liu · Paul Hofman · Robert Homer · Soo-Ryum Yang · Angela C. Pesatori · Dario Consonni · Lixing Yang · Bin Zhu · Jianxin Shi · Kevin Brown · Nathaniel Rothman · Stephen J. Chanock · Ludmil B.
11 August 2026 at 01:00

Nature, Published online: 11 August 2026; doi:10.1038/s41586-026-10947-0

Author Correction: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
Received — 25 July 2026 ⏭ Nature

CRISPR–Cas regulates expression of embedded anti-phage defence systems

✇Nature
By: Xian Shu · Rui Wang · Xufei Zhou · Feiyue Cheng · Jiayue Ma · Zhihua Li · Xin Li · Tuozhan Wu · Aici Wu · Qiong Xue · Chao Liu · Huiwei Zhao · Xifeng Cao · Lin Wang · Shouyue Zhang · Yan Zhang · Ming Li
22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.
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