❌

Normal view

Multimodal precision diagnostics in clinical xenotransplantation

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnostic framework is proposed to detect these injuries earlier, guide personalized immunosuppression and inform future gene editing strategies.

The contribution of salt marshes to wave attenuation during extreme storms

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11145-8

Salt marsh platforms resist erosion under extreme waves, but vegetation damage reduces wave attenuation; substantial wave attenuation by vegetation is mainly limited to low-energy marsh coasts with waves below 1 m.

Cold activates a BH2 metabolic network promoting longevity and proteostasis

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11152-9

A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.

WEE1 opposes APC/C<sup>CDH1</sup> activity to promote S phase entry

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x

Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

A single archaeon couples long-chain fatty acid oxidation to methanogenesis

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11207-x

Methanoglobus dolicholipophagus AA-75 is a thermophilic archaeon isolated from a Chinese petroleum reservoir that converts methanol into methane, carbon dioxide and acetate, and uses saturated and unsaturated fatty acids to produce methane.

An environmentally regulated dichotomy in cell lineages of the root

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11179-y

An environment-regulated state is identified across multiple cell types at the root tip, revealing a shared dichotomy between cells with and without this state.

CD51 delineates functionally distinct astrocyte subtypes in neural circuits

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11186-z

CD51+ astrocytes promote synapse formation in the developing cortex, circuit plasticity in the hippocampus and circuit remodelling after stroke.

Persistent neuronal stress signalling underlies Angelman syndrome phenotypes

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4

Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.
❌